STEROID RECEPTOR ANALYSES OF 9 HUMAN BREAST-CANCER CELL LINES

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (8) , 2434-2437
Abstract
Nine human breast cancer cell lines in permanent tissue culture and currently available to researchers were assayed for their content of cytoplasmic estrogen, progesterone, androgen and glucocorticoid receptors, as well as the presence of unfilled or hormone-filled nuclear estrogen receptors. Receptor distribution varied considerably among the 9 lines and differed from the expected distribution predicted from solid tumors. Estrogen receptor, when present, is usually localized in the nucleus as unfilled nuclear estrogen receptor. Progesterone receptor is correlated with the presence of unfilled nuclear estrogen receptor. Glucocorticoid receptors are ubiquitous. They were found in all cell lines tested. The distribution of androgen and progesterone receptors differed, suggesting that these proteins are dissimilar.