Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Detects Cortical and Juxtacortical Multiple Sclerosis Lesions

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Abstract
MULTIPLE sclerosis (MS) is commonly thought of as a multifocal disease of white matter of the central nervous system, but a growing body of evidence suggests that it is a more widespread, global disease of the brain.1-13 Tissue abnormalities have been detected pathologically8 and by magnetic resonance imaging (MRI)4,5,14,15 in grossly normal-appearing white matter distant from acute and chronic MS lesions. In addition, the MS disease process appears to extend to the cortical and subcortical gray matter.10-13,16