Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism

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Abstract
Summary: OBJECTIVE A high prevalence of diabetes mellitus has been shown in patients with primary hyperparathyroidism (PHPT). However, it is unclear whether this is related to the metabolic abnormalities in PHPT or to the presence of other risk factors for glucose intolerance in these patients. The aim of our study was to determine whether glucose intolerance and insulin insensitivity occur in subjects with PHPT who do not have other risk factors for diabetes mellitus.DESIGN Cross‐sectional study of glucose metabolism in PHPT patients without other risk factors for diabetes mellitus, compared to age and body mass index (BMI) matched healthy subjects.SUBJECTS Nineteen non‐obese, non‐diabetic, normotensive patients with PHPT and 11 age and BMI matched healthy subjects.MEASUREMENTS The continuous infusion of glucose test was used to assess glucose tolerance. Plasma glucose and insulin were measured during a 1‐hour continuous infusion of glucose (5 mg/kg ideal body weight/min); insulin sensitivity and beta‐cell function were derived from the glucose and insulin data by mathematical modelling. Fasting serum concentrations of parathyroid hormone, ionized calcium and 1,25‐dihydroxyvitamin D (1,25(OH)2D) were measured in all subjects.RESULTS PHPT patients attained higher plasma glucose levels at the end of the glucose infusion (median 9.0 (interquartile range 8.1–9.8) mmol/l) than did controls (7.9 (7.1–8.9) mmol/l, PPvs 120% (98.8–156.6) respectively, Prs=−0.21), 1,25(OH)2D (rs=−0.14), ionized calcium (rs=–0.11) and inorganic phosphate (rs= 0.34). Beta‐cell function did not correlate with PTH (rs= 0.15), 1,25(OH)2D (rs= 0.04), ionized calcium (rs= 0.23) or inorganic phosphate (r,=− 0.35).CONCLUSION Insulin insensitivity is present in PHPT even in the absence of hypertension and obesity, and may be the cause of glucose intolerance and diabetes. PHPT subjects with reduced beta‐cell function are more likely to develop glucose intolerance.