Effects of hydroxymalonate on the metabolism of brain

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Abstract
Na hydroxymalonate inhibits the oxidation of lactate by slices of rat and guinea-pig braina to a greater extent than it inhibits the oxidation of glucose and pyruvate. It is concluded that glucose can be oxidized in brain by a mechanism that does not involve lactate as an intermediary. Hydroxymalonate inhibits the anaerobic breakdown of pyruvate by brain, a simple colorimetric method for estimating pyruvic acid being used. Hydroxymalonate inhibits the anaerobic glycolysis of brain in the absence or presence of pyruvate. Phosphoglycerate does not raise the respiration of brain appreciably either in the absence or presence of [alpha]-glycerophosphate. These results are discussed with reference to the Embden-Meyerhof scheme.