Modulation of Calcium Ion Influx by the 1,4-Dihydropyridines Nifedipine and BAY K 8644
- 1 May 1985
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 7 (3) , 493-496
- https://doi.org/10.1097/00005344-198505000-00012
Abstract
The effects of the new dihydropyridine Ca agonist BAY K 8644 [1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridinecarboxylic acid methyl ester] on Ca influx and mechanical activity was examined in rabbit aortic rings and compared with those of the classical Ca antagonist nifedipine. The vasodilating effects of nifedipine and the vasoconstricting effects of BAY K 8644 were explained by the Ca influx modulating activity of these 2 dihydropyridines. Only at the high concentration of 3 .times. 10-6 mol/l BAY K 8644 was there a marked difference between increased Ca influx and reduced contraction.This publication has 9 references indexed in Scilit:
- Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonistsNature, 1984
- Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.Proceedings of the National Academy of Sciences, 1984
- Voltage-sensitive calcium flux promoted by vesicles in an isolated cardiac sarcolemma preparationThe Journal of Membrane Biology, 1984
- Specific binding of a calcium channel activator, [3H]BAY k 8644, to membranes from cardiac muscle and brainBiochemical and Biophysical Research Communications, 1984
- Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridineBiochemical and Biophysical Research Communications, 1984
- Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.Journal of Biological Chemistry, 1983
- A unitary mechanism of calcium antagonist drug action.Proceedings of the National Academy of Sciences, 1983
- ACTIONS OF NIFEDIPINE ON CALCIUM FLUXES AND CONTRACTION IN ISOLATED RAT ARTERIES1983
- CHARACTERIZATION OF BINDING OF THE CA++ CHANNEL ANTAGONIST, [H-3]-LABELED NITRENDIPINE, TO GUINEA-PIG ILEAL SMOOTH-MUSCLE1983