Emerging links between hypermutation of antibody genes and DNA polymerases
- 1 December 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 1 (3) , 187-192
- https://doi.org/10.1038/35105009
Abstract
Substantial antibody variability is created when nucleotide substitutions are introduced into immunoglobulin variable genes by a controlled process of hypermutation. Evidence points to a mechanism involving DNA repair events at sites of targeted breaks. In vertebrate cells, there are many recently identified DNA polymerases that inaccurately copy templates. Some of these are candidates for enzymes that introduce base changes during hypermutation. Recent research has focused on possible roles for DNA polymerases ζ (POLZ), η (POLH), ι (POLI), and μ (POLM) in the process.Keywords
This publication has 70 references indexed in Scilit:
- Structure of the Catalytic Core of S. cerevisiae DNA Polymerase ηMolecular Cell, 2001
- DNA polymerase mu, a candidate hypermutase?Philosophical Transactions Of The Royal Society B-Biological Sciences, 2001
- The reverse transcriptase model of somatic hypermutationPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2001
- Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cellsGenes & Development, 2001
- DNA polymerase lambda (Pol λ), a novel eukaryotic DNA polymerase with a potential role in meiosis 1 1Edited by M. YanivJournal of Molecular Biology, 2000
- Cloning and Chromosomal Mapping of the Human DNA Polymerase θ (POLQ), the Eighth Human DNA PolymeraseGenomics, 1999
- Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutantsEuropean Journal of Immunology, 1996
- Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription InitiationImmunity, 1996
- Somatic hypermutation of an immunoglobulin transgene in K transgenic miceNature, 1987
- Variability in the Lambda Light Chain Sequences of Mouse AntibodyNature, 1970