The Swelling and Extractability of Human Sponge-Biopsy Connective Tissue

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Abstract
Parameters used to measure the effect of aging are thought to be 2 kinds: an "integrated" quantity results when the host''s chronological age is comparable to that of the particular structure studied. When the host''s age is large relative to the structure of interest, then a "differential" parameter results. The sponge-biopsy technique was used to obtain "differential" samples of connective tissue; a study was made of the effect of chronological donor age (Alaskan Indians) on the swelling and extractability in 0.5 [image] acetic acid of this tissue. The extent of swelling of "differential" connective tissue decreased with increased chronological age of the tissue donors, a finding consistently observed by others using "integrated" tissue samples. The extractability of nitrogenous constituents from the sponge-biopsy obeyed a simple empirical expression; thus, log (concentration) vs. extraction number was a linear plot from which the acetic acid-soluble fraction and insoluble residue were described. The former did not change whereas the insoluble residue became greater with increased donor age.