Effect of Duodenal Acidification or Exogenous Secretin on Gastric Acid Secretion Stimulated by Histamine, Pentagastrin or Human Gastrin I in Conscious Cats

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Abstract
In conscious cats with gastric fistulas (GF) and Heidenhain pouches (HP), closing the GF, or closing the GF and infusing 1.8 mEq/hour of hydrochloric acid through the GF did not alter histamine or pentagastrin stimulated acid secretion from the HP. In conscious GF cats a rapid i.v. injection of 5 or 20 U/kg of secretin did not alter histamine stimulated acid secretion but reduced pentagastrin and gastrin stimulated secretion by 30–40%. The results suggest that physiological amounts of acid entering the duodenum do not inhibit pentagastrin stimulated acid secretion from the HP in cats in contrast to in dogs

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