A Family with Allo-Immune Neonatal Neutropenia: Group-Specific Pathogenicity of Maternal Antibodies

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Abstract
A family is presented, in which the mother developed strong neutrophil granulocyte-specific antibodies [Ab] with the specificity anti-NA1. The 1st and 3rd children, both NA1-positive, suffered from severe transient neonatal neutropenia, but the 2nd child, NA1-negative, did not. Anti-NA1 Ab were detectable in the serum of 1 affected child and the Ab level was directly related to the extent of neutropenia. The incidence of granulocyte-specific Ab in 198 pregnant women was low.