The Rhesus Monkey as an Animal Model for Age-Related Maculopathy

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Abstract
In a survey of 100 rhesus monkeys, the prevalence of macular changes was similar to that in age-related macular degeneration in humans. Ophthalmoscopically visible drusen was observed in 31% of the monkeys. A statistically significant correlation existed between the age of the animals and the degree of drusen. Considering equivalent ages, monkeys appear to develop drusen earlier than humans. Pigment mottling occurredin 10% and hypopigmented spots in 8% of the sample. A dull foveal refelx was seen in 8% and no reflex in 27%. There was a statistically significant correlation between the absence of a reflex and the presence of pigment mottling or hypopigmentation in the macula.

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