COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics
- 21 February 2001
- journal article
- review article
- Published by Wiley in Journal of Chemical Technology & Biotechnology
- Vol. 76 (3) , 237-244
- https://doi.org/10.1002/jctb.363
Abstract
An overview of the COMPACT method for evaluating potential toxicity mediated by cytochrome P450 enzymes is presented. Particular aspects of P450s are described, together with details of QSARs and homology modelling of mammalian P450s associated with foreign compound metabolism.© 2001 Society of Chemical IndustryKeywords
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