PROLACTIN AND 3‐METHYLCHOLANTHRENE INDUCED CERVICAL CARCINOMA. EFFECT OF BROMOCRIPTINE

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Abstract
Female mice of the NMRI strain were injected with estradiol for the first 5 days after birth (estrogenized animals) and ovariectomized at the age of 6-9 wk. One wk later, a cotton thread impregnated with 3-methylcholanthrene was inserted into the uterine cervix. Starting on the day of insertion of the thread, and for a further 6 days, the females were injected with estradiol (E2), ovine prolactin (P) or 2-bromo-.alpha.-ergokryptine mesylate (bromocriptine). Controls were injected with vehicles only. The animals were killed 4 or 8 wk after insertion of the thread, and the uterine cervix was serially sectioned. A combined treatment with E2 and P resulted in an increased incidence of invasive epithelial lesions in the uterine cervix. This incidence was higher than in controls or females injected with either hormone separately. Bromocriptine reduced the incidence of invasions, and this reduction could not be restored to the control level by a simultaneous treatment with E2 and/or P. Finally, the incidence of invasive lesions in the control group of estrogenized females was higher than that reported in an earlier study using non-estrogenized females.