Polyploidy in the pancreas of the normal and diabetic mutant mouse
- 1 May 1976
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 12 (2) , 167-170
- https://doi.org/10.1007/bf00428984
Abstract
The DNA content of endocrine and exocrine pancreatic nuclei of normal C57BL/KsJ and diabetic mutant C57BL/Ks-db/db mice was measured by Feulgen microdensitometry. The exocrine and endocrine pancreatic nuclei of the 4-week-old normal, 12-week-old normal, and 4-week-old (prehyper-glycaemic) diabetic mutant mice contained diploid and tetraploid cells, while the 12-week-old (established hyperglycaemic) mutant contained diploid, tetraploid, and octaploid nuclei. The polyploidy in the endocrine pancreas of all these mice was confined to the B-cells, while the A-cells were always diploid.This publication has 10 references indexed in Scilit:
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