ACCUMULATION AND RELEASE OF THYROID HORMONES BY THE NORMAL AND DISEASED HUMAN LIVER

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Abstract
In patients with liver cirrhosis the rate of disappearance of radioactivity from the blood during the 20 to 50 minute interval following the intravenous injection of 131I labelled L-T4 has been found to be markedly delayed compared to normal subjects. That this delay is due mainly to decreased hepatic uptake, was shown by a reduced 10 minute hepatic uptake of this labelled hormone. The principle binding proteins for T4 were not affected in a manner that would increase serum binding of the hormone. The 10 minute hepatic uptake of 131I labelled L-T3 was also reduced in the cirrhosis group, suggesting that the normal liver also contains binding sites for T3, and these are diminished in cirrhosis.

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