The Structure of Ikarugamycin, an Acyltetramic Acid Antibiotic Possessing a Unique as-Hydrindacene Skeleton

Abstract
The structure and configuration of an antibiotic, ikarugamycin, have been established to be 1e on the basis of chemical reactions, especially of oxidative degradation. It is suggested that the as-hydrindacene skeleton arises biogenetically via an intramolecular Diels-Alder reaction.