SODIUM-BROMIDE AND SODIUM VALPROATE - EFFECTIVE SUPPRESSANTS OF ETHANOL WITHDRAWAL REACTIONS IN MICE

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 208  (2) , 223-227
Abstract
Mice were made physically dependent on ethanol by a 3-day alcohol inhalation regimen, using pyrazole to stabilize blood ethanol concentrations. After withdrawal, convulsions elicited by handling were scored repeatedly for 30 h as a measure of CNS hyperexcitability. Administration of sodium bromide, 0.2-2.0 g/kg i.p., suppressed the convulsions in a dose-related fashion. Bromide was effective at subsedative doses, but increased the postwithdrawal mortality. Bromide may act at chloride channels, as GABA does. Valproate and its amide temporarily suppressed the withdrawal reaction at doses that caused some sedation. Muscimol and .beta.-alanine had no effect.

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