TOTAL SYNTHESIS OF 14-FLUOROPROSTAGLANDIN F2α AND 14-FLUOROPROSTACYCLIN
- 5 September 1978
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 7 (9) , 1001-1004
- https://doi.org/10.1246/cl.1978.1001
Abstract
The synthesis of (±)-14-fluoroPGF2α methyl ester (1), (±)-15-epi-14-fluoroPGF2α methyl ester (12), and (±)-14-fluoroprostacyclin (2) is detailed. Prostaglandins 1 and 12 have been evaluated for pregnancy interruption in the hamster and smooth muscle stimulating effects on gerbil colon and hamster uterine strips. Prostacyclin 2 was evaluated for inhibition of human blood platelet aggregation and dilation of the isolated perfused cat coronary artery.This publication has 8 references indexed in Scilit:
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