Some Effects of 2-Deaminopteroylglutamic Acid upon Bacterial Growth
- 1 December 1953
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 9 (3) , 536-544
- https://doi.org/10.1099/00221287-9-3-536
Abstract
An analogue of pteroyl-glutamic acid, 2-deaminopteroylglutamic acid, did not stimulate growth of Streptococcus faecalis R and Lactobacillus casei. When pteroic acid or pteroylglutamic acid is present as a source of folic acid, 2-deaminopteroylglutamic acid is an effective inhibitor. If leucovorin or rhizopterin is used as the folic acid source, this inhibition is much less marked. When L. casei is grown on a medium containing thymine and a purine, the subopt. growth obtained can be stimulated by 2-deaminopteroylglutamic acid.Keywords
This publication has 10 references indexed in Scilit:
- COMPARATIVE STUDIES WITH THE NATURAL AND SYNTHETIC CITROVORUM FACTORJournal of Biological Chemistry, 1952
- PTEROYLGLUTAMIC ACID ANTAGONISTSAnnals of the New York Academy of Sciences, 1950
- On the Mechanism of Action of Aminopterin.Experimental Biology and Medicine, 1950
- STUDIES ON THE INHIBITORY NATURE OF 4-AMINOPTEROYLGLUTAMIC ACIDJournal of Biological Chemistry, 1948
- FORMYLFOLIC ACID, A FUNCTIONAL DERIVATIVE OF FOLIC ACIDJournal of the American Chemical Society, 1948
- THE SYNTHESIS OF FOLIC ACID BY STREPTOBACTERIUM-PLANTARUM AND ITS INHIBITION BY SULPHONAMIDES1948
- BIOCHEMICAL TRANSFORMATIONS AS DETERMINED BY COMPETITIVE ANALOGUE-METABOLITE GROWTH INHIBITIONS .7. RELATIONSHIP OF PURINES AND THYMINE TO FOLIC ACID1948
- GROWTH INHIBITION OF BACTERIA BY SYNTHETIC PTERINS .1. STUDIES WITH STREPTOCOCCUS FAECALIS, LACTOBACILLUS CASEI, AND LACTOBACILLUS ARABINOSUS1947
- THE VITAMIN-B6 GROUP .11. AN IMPROVED METHOD FOR ASSAY OF VITAMIN-B6 WITH STREPTOCOCCUS FAECALIS1947
- Substitution of Thymine for “Folic Acid” in the Nutrition of Lactic Acid BacteriaJournal of Bacteriology, 1944