Mechanisms for reactions of halogenated compounds. Part 6. Investigations into the activating effect of ortho-fluorine in nucleophilic aromatic substitution
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 255-257
- https://doi.org/10.1039/p19880000255
Abstract
Separate activating effects for ortho- and meta-fluorine, on nucleophilic aromatic substitution, are determined for pyrimidine and pyridine systems. Comparisons confirm the importance of ion–dipole interactions for activation by ortho-fluorine. The effects of ortho-fluorine on anionic σ-complexes are also discussed.Keywords
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