Role of Folate Binding Proteins in Folate Metabolism

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Abstract
The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate- dependent intracellular enzymes. We outline changes in plasma folate-binding proteins in various clinical states, review their postulated functions, detail the biochemistry of mammalian soluble folate-binding proteins and their membrane-bound immunologically cross-reactive possible precursors, and present evidence that the latter proteins may function as the physiologic folate receptors and intracellular regulators of folate coenzyme availability. Keywords Human Milk Brush Border Membrane Folate Uptake Folate Absorption Folate Content These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.