Interrelationships between pulmonary blood flow and bronchomotor tone: Po2 and Pco2.

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Abstract
In the anesthetized dog, the left lower lobe was ventilated and perfused separately from the other lobes. The bronchodilatation resulting from a primary increase in lobar blood flow of the left lower lobe is brought about by an elevation in carbon dioxide tension in the alveolar air. The local administration of low oxygen mixture to the same lobe caused a bronchoconstriction by indirectly reducing the carbon dioxide tension. Systemic hypercapnia and anoxia caused bronchoconstriction by increasing vagal tone. All of these responses are important in the regulation of ventilation and perfusion to a lobe.

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