PROTEIN-SYNTHESIS IN HEART-MITOCHONDRIA - MECHANISM AND METABOLIC ASPECTS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (1) , 1-13
Abstract
The inhibitory effects of an antibiotic such as chloramphenicol and thiamphenicol are discussed from the point of possible complications for cardiac metabolism. A decrease of the activity of cytochrome c oxidase, the terminal enzyme of the respiratory chain, causes an increase in the production of lactate, if beating heart cells are cultured in the presence of chloramphenicol. In vivo treatment of rabbits with the chloramphenicol analogue thiamphencol causes a strong fall in the cytochrome aa3 content of the hearts. The results are discussed in the light of the possible implications for cardiac function and metabolism in man.

This publication has 0 references indexed in Scilit: