Ligand distortion modes leading to increased chirality content of Katsuki‐Jacobsen catalysts
- 1 January 2002
- Vol. 14 (8) , 677-682
- https://doi.org/10.1002/chir.10118
Abstract
The “chirality content” of Katsuki-Jacobsen epoxidation catalysts are computed with the Avnir continuous chirality measure (CCM). An assessment of Mn(salen) molecules from the Cambridge Structural Database shows there exist some variation in CCM and the chirality content for several triplet state complexes of these catalysts purported in the literature to be the active species show even larger CCM values. Several deformation modes were analyzed to examine how chirality content changes as catalyst distortion is induced. The deformations studied include in-plane deformations, cup-shaped puckering, ligand twisting motions, and step-like deformations. Some distortions lead to increases of chirality while others lead to a decrease in chirality content. The most influential distortion modes that can be used for ligand design are twisting and step induction. Chirality 14:677–682, 2002.Keywords
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