Encephalomyelitis Due to Infection withHerpesvirus simiae(Herpes B Virus)

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Abstract
HERPESVIRUS simiae, or herpes B virus, may apparently cause similar clinical manifestations in monkeys as Herpesvirus hominis, or the virus of herpes simplex, in man. Both viruses are closely related morphologically, biologically and antigenically. Rarely do these agents cause severe clinical illnesses in their respective natural hosts. The usual clinical disease, as a result of primary infection, is a stomatitis, and oral-carrier states are frequently encountered. Accidental inoculation of H. simiae into man, on the other hand, may lead to severe encephalomyelitis, usually with fatal consequences. Prevention of the disease in man depends upon a comprehensive safety program. Any institution . . .