Effect of Lidoflazine on Systemic Arteries and Veins

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Abstract
Therapeutic agents that decrease the preload of the heart (by causing peripheral venodilatation) and/or its afterload (by decreasing arteriolar resistance) decrease the amount of work that the myocardium has to perform; these agents help the failing or ischemic heart to meet circulatory demands. Lidoflazine improves work tolerance in patients with ischemic heart disease. A direct inhibitory action of lidoflazine on the vascular smooth muscle cells of the systemic pre- and postcapillary vessels was evaluated. The effects of increasing concentrations of lidoflazine on the isolated arteries and veins of dogs were investigated.