Anti‐miR‐155 oligonucleotide enhances chemosensitivity of U251 cell to taxol by inducing apoptosis

Publisher Website
Google Scholar
Abstract
The oncogene, microRNA‐155, is significantly elevated in GBM (glioblastoma multiforme), regulating multiple genes associated with cancer cell proliferation, apoptosis and invasiveness. Thus, miR‐155 can theoretically become a target for enhancement of the chemotherapy in cancer. Down‐regulating miR‐155 to enhance the effect of taxol has not been studied in human GBM. Human GBM U251 cells were treated with taxol and the miR‐155 inhibitor alone or in combination. IC50 values were dramatically decreased in cells treated with miR‐155 inhibitor combined with taxol, to a greater extent than those treated with taxol alone. Furthermore, the miR‐155 inhibitor significantly enhanced apoptosis in U251 cells. The data suggest that miR‐155 blockage increased the chemosensitivity to taxol in GBM cells, making combined treatment an effective therapeutic strategy for controlling the growth by inhibiting EAG1 expression.