Urodilatin (CDD/ANP‐95‐126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (α‐hANP/CDD‐99‐126)

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Abstract
Atrial natriuretic peptide (CDD/ANP‐99‐126) is rapidly inactivated by a membrane preparation from dog kidney cortex. Inactivation occurs by cleavage of the ring structure in the position between Cys‐105 and Phe‐106. A unique proteolytic product separated by HPLC on reverse‐phase column appears as a single peak which elutes prior the intact peptide. In contrast, CDD/ANP‐95‐126 (urodilatin) which is released from the kidney is not destroyed by proteolysis using an identical membrane preparation.