Motor inhibition from the brainstem is normal in torsion dystonia during REM sleep.
Open Access
- 1 February 1991
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 54 (2) , 140-144
- https://doi.org/10.1136/jnnp.54.2.140
Abstract
The maintenance of axial atonia during REM sleep was monitored in 14 patients with primary torsion dystonia, 10 patients with secondary torsion dystonia, and 10 normal subjects using submental EMG and video EEG telemetry. The excitability of the corticospinal tract during REM sleep was also assessed using scalp magnetic stimulation in seven patients and three controls. During REM sleep dystonic patients had well maintained atonia evidenced by infrequent bursts of submental activity, no episodes of complex semi-purposeful behaviour and reduced motor responses to magnetic stimulation. These findings suggest that the inhibitory centres in the region of the locus coeruleus and their descending pathways to the spinal alpha motor neurons are intact in torsion dystonia.Keywords
This publication has 23 references indexed in Scilit:
- Sleep Spindles in Torsion DystoniaArchives of Neurology, 1990
- Pathological report of four patients presenting with cranial dystoniasMovement Disorders, 1988
- Excitability of the human motor cortex is enhanced during REM sleepNeuroscience Letters, 1987
- Brain Neurotransmitters in DystoniaNew England Journal of Medicine, 1987
- Brain Neurotransmitters in Dystonia Musculorum DeformansNew England Journal of Medicine, 1986
- Subthreshold Excitatory Activity and Motoneuron Discharge During REM Periods of Active SleepScience, 1983
- Rostral brainstem contributes to medullary inhibition of muscle toneBrain Research, 1983
- Different behaviors during paradoxical sleep without atonia depend on pontine lesion siteBrain Research, 1982
- Neuronal activity specific to paradoxical sleep in the ventromedial medullary reticular formation of unrestrained catsBrain Research, 1980
- Le comportement onirique du chatPhysiology & Behavior, 1979