Extraction of 6-Monoacetylmorphine from Urine*
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 14 (1) , 58-59
- https://doi.org/10.1093/jat/14.1.58
Abstract
An efficient and improved procedure for the extraction of 6-monoacetylmorphine (6-MAM) from urine is described. The procedure uses a 10% isobutanol in methylene chloride solution for initial extraction of 6-MAM, back extraction with acidic sodium acetate, and then another alkaline extraction into 10% isobutanol in methylene chloride. Compared to solid-phase extraction, this method provided significant improvement in 6-MAM recovery, along with the elimination of extraneous peaks when analyzed by GC/MS.This publication has 3 references indexed in Scilit:
- Rendering the "poppy-seed defense" defenseless: identification of 6-monoacetylmorphine in urine by gas chromatography/mass spectroscopy.Clinical Chemistry, 1988
- Detection of O6-Monoacetylmorphine in Urine Samples by GC/MS as Evidence for Heroin UseJournal of Analytical Toxicology, 1985
- Morphine intake from poppy seed foodJournal of Pharmacy and Pharmacology, 1982