Transcription-Induced Cytosine-to-Thymine Mutations Are Not Dependent on Sequence Context of the Target Cytosine
Open Access
- 1 November 2001
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 183 (21) , 6491-6493
- https://doi.org/10.1128/jb.183.21.6491-6493.2001
Abstract
We showed previously that transcription of a plasmid-borne kan allele increases C-to-T mutations in the nontranscribed strand. Using two new plasmid-borne kan alleles, one cmp allele, and a chromosomal kan allele, we found in this study that transcription-induced mutations are not limited to specific genes, alleles, or locations and are likely to be a general property of transcript elongation in Escherichia coli .Keywords
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