Hb Marseille [α2β2N methionyl - 2 (NA2) His → Pro]: a new β chain variant having an extended N-terminus
- 10 December 1984
- journal article
- case report
- Published by Wiley in FEBS Letters
- Vol. 178 (2) , 315-318
- https://doi.org/10.1016/0014-5793(84)80624-9
Abstract
A new abnormal hemoglobin was found in a diabetic Maltese woman by citrate agar electrophoresis. This variant was undetectable by isoelectric focusing. No hematological abnormalities were observed. The structural analysis included isolation of the abnormal β chain, high pressure liquid chromatography of the corresponding tryptic peptides and then microsequencing of the abnormal T1. These procedures revealed a double abnormality: the presence of a methionyl residue extending the NH2 terminus and a histidine to proline substitution in position NA2.Keywords
This publication has 22 references indexed in Scilit:
- An automatic method for determination of glycosylated hemoglobins using low-pressure liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1983
- Globin Chain Electrophoresis: a New Approach to the Determination of the Gγ/Aγ Ratio in Fetal Haemoglobin and to Studies of Globin SynthesisBritish Journal of Haematology, 1980
- A Silent Hemoglobin Variant: Hemoglobin Necker Enfants-Malades α 20 (Bl) His → TyrHemoglobin, 1980
- Separation of tryptic peptides of normal and abnormal a, β, γ, and δ hemoglobin chains by high-performance liquid chromatographyJournal of Chromatography A, 1979
- Methods for Detection of Hemoglobin Variants and Hemoglobinopathies in the Routine Clinical LaboratoryCRC Critical Reviews in Clinical Laboratory Sciences, 1978
- A Simple Method for the Detection of Unstable HaemoglobinsBritish Journal of Haematology, 1972
- Hemoglobin Components in Patients with Diabetes MellitusNew England Journal of Medicine, 1971
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Combinations of specific color reactions useful in the peptide mapping techniqueBiochimica et Biophysica Acta (BBA) - General Subjects, 1965
- Estimation of Small Percentages of Fœtal HæmoglobinNature, 1959