Enzymatic Synthesis of Stereoregular (All Rp) Oligonucleotide Phosphorothioate and Its Properties

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 985-990
https://doi.org/10.1080/15257779508012517

Abstract

A protocol has been established for the synthesis of stereoregular (all Rp) oligonucleotide phosphorothioates. A 25-mer oligodeoxynucleotide phosphorothioate has been synthesized and studied for biophysical and biochemical properties.

Keywords

ENZYMATIC SYNTHESIS
STEREOREGULAR
BIOCHEMICAL PROPERTIES
MER OLIGODEOXYNUCLEOTIDE
OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE
BIOPHYSICAL

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