Platelet integrins and immunoreceptors
- 9 July 2007
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 218 (1) , 247-264
- https://doi.org/10.1111/j.1600-065x.2007.00532.x
Abstract
Summary: Stable platelet adhesion to extracellular matrices and the formation of a hemostatic or pathological thrombus are dependent on integrin αIIbβ3, also known as GPIIb–IIIa. However, maximal platelet responses to vascular injury may involve the participation of other integrins expressed in platelets (αVβ3, α2β1, α5β1, and α6β1). Platelet membrane ‘immunoreceptors’ contain at least one subunit with an extracellular immunoglobulin superfamily domain and/or an intracellular stimulatory immunoreceptor tyrosine‐based activation motif (ITAM) or immunoreceptor tyrosine‐based inhibitory motif (ITIM). Platelet ITAM receptors, such as FcγRIIA and the GPVI–FcRγ complex, promote activation of integrins, while ITIM receptors, such as platelet–endothelial cell adhesion molecule‐1, may promote their inhibition. This review summarizes the structure and function of platelet integrins and immunoreceptors, the emerging functional relationships between these receptor classes, and the consequences of their interaction for platelet function in hemostasis and thrombosis.Keywords
This publication has 267 references indexed in Scilit:
- The role of platelet adhesion receptor GPIbα far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosisProceedings of the National Academy of Sciences, 2006
- The Synergy Site of Fibronectin Is Required for Strong Interaction with the Platelet Integrin αIIbβ3Annals of Biomedical Engineering, 2006
- Integrin structures and conformational signalingCurrent Opinion in Cell Biology, 2006
- Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activationBiochemical and Biophysical Research Communications, 2005
- IntegrinsCell, 2002
- The Role of the Specificity-Determining Loop of the Integrin β Subunit I-like Domain in Autonomous Expression, Association with the α Subunit, and Ligand BindingBiochemistry, 2002
- The P2Y12 receptor induces platelet aggregation through weak activation of the αIIbβ3 integrin – a phosphoinositide 3‐kinase‐dependent mechanismFEBS Letters, 2001
- Blood Platelets Contain and Secrete Laminin-8 (α4β1γ1) and Adhere to Laminin-8 via α6β1 IntegrinExperimental Cell Research, 1999
- The Secondary Structure of the von Willebrand Factor type A Domain in Factor B of Human Complement by Fourier Transform Infrared Spectroscopy: Its Occurrence in Collagen Types VI, VII, XII and XIV, the Integrins and Other Proteins by Averaged Structure PredictionsJournal of Molecular Biology, 1994
- Isolation of α6β1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragmentExperimental Cell Research, 1991