TC-99M-LABELED POLYSTYRENE AND CELLULOSE MACROMOLECULES - AGENTS FOR GASTROINTESTINAL SCINTIGRAPHY

  • 1 January 1982
    • journal article
    • research article
    • Vol. 23  (8) , 693-697
Abstract
Several polystyrene resin and cellulose derivatives were evaluated for potential use as 99mTc-labeled particulate markers for studies of gastric emptying and intestinal transit time and for imaging segments of the gastrointestinal tract. The polyamine and quaternary ammonium polystyrene resins bound pertechnetate (99mTc) anions effectively; the labeling efficiency was > 95% at physiological pH values. In vitro stability studies of 99mTc-labeled resins in simulated gastric and intestinal fluid showed that < 8% of the label was released after 24 h. The commercial resins Dowex 2-X8, AG 1-X2 and Bio-Rex 9, labeled with 99mTc, may be used as particulate markers of solid digesta in external scintigraphic studies of the gastrointestinal tract. Dowex 2-X8 showed relatively more extensive uptake of pertechnetate and greater stability in simulated gastric and intestinal fluids.