Renal Allografts and Donor Spleen Cells

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Abstract
Donor spleen cell Infusions were given to dogs receiving renal allografts. Those animals which were pretreated with spleen cells achieved graft survival double that of controls. Animals treated after grafting achieved no significant enhancement over the untreated control dogs. The experimental groups, as well as a group of animals who received only spleen cells, showed no toxic reactions to treatment. Pretreatment of adult animals with donor spleen cells offers some promise for achieving specific immunologic tolerance to organ allografts. Although current tolerance is far less than that achieved with antimetabolites, the potential goal of safe and specific immunosuppression is more desirable than general Immunosuppression alone.