Vitamin D-induced coronary atherosclerosis in normolipemic swine: Comparison with human disease.

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Abstract
Coronary atherosclerosis developed in normolipemic swine fed a basal ration supplemented with 125,000, 62,500 and 31,250 IU of vitamin D3/kg of diet for 3 mo. and the basal ration for the following 3 mo. Lesions consisted of intimal atheromata and calcified internal elastica and caused luminal narrowing. The incidence of atherosclerotic lesions was proportional to the vitamin D3 doses. The present experimentally induced lesions had many morphological features resembling those in coronary arteries from human subjects.