Reactions in Canine Skin with Human Leukocyte Lysates

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Abstract
Two types of local reactions in canine skin were observed after intradermal injection of chromatographically prepared fractions of human peripheral blood leukocyte lysates. The 1st reaction peaked within 4 h after injection, appeared unrelated to antigen, and was characterized by a mild diffuse mononuclear and polymorphonuclear infiltrate in the s.c. tissue. The 2nd response peaked 30 h after the injection of antigen onto the site previously prepared with leukocyte lysate. This response appeared to be antigen specific, and was characterized by an early perivascular mononuclear infiltrate followed by a diffuse mononuclear and polymorphonuclear accumulation in the s.c. region. Peaks 1 and 4 most consistently gave positive results.

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