Synthesis and in vitro evaluation of 8-hydroxyquinoline analogs as inhibitors of dental plaque
- 1 January 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (1) , 167-169
- https://doi.org/10.1021/jm00223a031
Abstract
A group of 5-substituted 8-hydroxyquinolines with predicted log P [partition coefficient] values in the 1-4 range were prepared from either 8-hydroxyquinoline or its appropriate derivative. 5-Formyl-, 5-iodo-, 5-fluoro-, 5-acetyl- and 5-methoxymethyl-8-hydroxyquinoline in addition to methyl 5-(8-hydroxyquinolyl)acetate and ethyl 5-(8-hydroxyquinolyl)acetate displayed greater in vitro antiplaque activity than 8-hydroxyquinoline. [Streptococcus mutans was used.].This publication has 0 references indexed in Scilit: