Endogenous Histamine in Male Organs of Reproduction

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Abstract
Histamine was found to be present in the testes, seminal vesicles and prostate glands of the mouse, rat and rabbit. Sex accessory organs contained much higher concentrations of histamine than did testicular tissue. Following castration, the concentration (μg/g) of this amine was consistently elevated in accessory organs of reproduction, the greatest increases occurring in the prostate glands. Changes in the total amount of histamine in these organs (μg/organ) following castration were not as marked and were found to vary with the species, increasing in the rat and decreasing in the mouse and rabbit. Testosterone propionate administration prevented the increase in histamine concentration and content normally seen in the castrate rat. Results from these studies suggest that previously described sex differences in histamine metabolism, at least in the rat, may be related to sex accessory tissue. (Endocrinology76: 839, 1965)

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