Experimental Herpes Simplex Infection in the Owl Monkey.

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Abstract
The owl monkey, Aotus trivirgatus, was highly susceptible to a strain of Herpesvirus hominis when inoculated by the ocular route and also by contact with infected monkeys. The infection developed rapidly with spread to the lungs, blood stream and particularly the liver and adrenal glands. Clinically the animals became sick 48 hr. after inoculation and died of a generalized infection after 4 to 6 days. Virus was recovered from ocular and pharyngeal secretions, the blood, urine and stool during life and from many organs, including liver, lungs, kidneys, adrenal, thymus, lymph glands, brain and spinal cord at autopsy. Pathologically the generalized infection was characterized by hemorrhagic pneumonitis and focal necrosis of the liver and adrenal glands.

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