EFFECT OF THIAMINE ON SEROTONIN OXIDATION IN MAGNESIUM-DEFICIENT RATS
Open Access
- 1 January 1974
- journal article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 20 (1) , 27-33
- https://doi.org/10.3177/jnsv.20.27
Abstract
To clarify the effect of thiamine on serotonin-related metabolism in magnesium-deficient rats, in vivo and in vitro experiments were carried out. In thiamine-excess magnesium-deficient and thiamine-adequate magnesium-deficient rats, serotonin oxidation activity in liver and stomach decreased significantly, while a decrease was not observed in thiamine-deficient magnesium-deficient rats. In vitro addition of a metal chelating agent and either thiamine or thiamine pyrophosphate to brain and liver mitochondria of intact rats resulted in a decrease in serotonin oxidation activities. Thus it is assumed that excess thiamine coupled with magnesium deficiency plays a role in the inhibition of serotonin oxidation and consequently serotonin increase.Keywords
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