SUBSEQUENT FERTILITY AND BIRTH HISTORIES OF CHILDREN AND ADOLESCENTS TREATED WITH I-131 FOR THYROID CANCER

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (6) , 460-464
Abstract
Forty patients aged 20 yr or less who were treated with 131I after surgery for papillary-follicular thyroid carcinoma were contacted for followup study. Five died and 2 were unmarried. The remaining 33 were studied with respect to their subsequent reproductive histories and the health of the offspring. The mean age at the time of the 1st 131I therapeutic dose was 14.6 yr (range 6-20), and the average followup interval, from that 1st dose until followup, was 18.7 yr (range 14-25). The mean total dose of 131I was 196 mCi (range 80-691). The incidences of infertility (12%), miscarriage (1.4%), prematurity (8%) and major congenital anomaly (1.4%) found in this series are not significantly different from those in the general population. This study offers no overt evidence of genetic damage in children and adolescents treated with high doses of 131I for thyroid carcinoma.

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