Effects ofcis-diamminedichloroplatinum (CDDP) andcis-diammine (1,1-cyclobutanedicarboxylate) platinum (CBDCA) on thermotolerance development and thermosensitivity of the thermotolerant cells

Publisher Website
Google Scholar
Abstract
The interactive effects of combined treatment with heat and CDDP (0.5 .mu.g/ml) or CBDCA (10 .mu.g/ml) were examined on the surviving fractions of V-79 cells. Both CDDP and CBDCA treatment induced a slight enhancement in thermosensitivity of thermotolerant cells. The development of thermotolerance during step-up heating was partially inhibited by simultaneous treatment with CDDP or CBDCA throughout the heating process. Simultaneous heat treatment at 42.degree. C with either drug showed marked interactive effect and inhibited the thermotolerance developed during 42.degree. C heating.