Property of kinin-forming enzyme in rat stomach.

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Abstract
The effects of inhibitors on the kinin-forming enzyme (KFE) activity in the rat stomach were investigated at pH 4.8. The KFE activity was unaffected by trasylol (200 KIU/ml), soybean trypsin inhibitor (100 .mu.g/ml) and p-tosyl-L-lysine chloromethyl ketone (10-3 M) but was inhibited by pepstatin A (10-6 M) and chymostatin (1.5 .times. 10-4 M). Each product from the rat plasma kininogen by the rat stomach KFE and the bovine spleen cathepsin D was eluated at the same retention time on the equilibrium chromatography on the SP-Sephadex C-25 column. The KFE activity in the rat stomach was considerably high compared with that in various regions of the intestine. The KFE is characteristically similar to cathepsin D and the enzyme is probably relevant to the function of the stomach.

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