A mimicking red blood cell autoantibody accompanying transfusion and alloimmunization

Publisher Website
Google Scholar
Abstract
A patient with sickle cell disease who concomitantly developed red cell autoimmunity and alloimmunization is reported. The implied but wrong specificity of the autoantibody mimicked one of the alloantibodies in the patient''s serum. Although the patient''s red blood cells phenotyped as Ror, anti-rh" was eluted from them on several occasions. Absorption and secondary elution from selected cells proved the cell bound antibody had a unique and independent specificity from the anti-rh" in this serum. Standard antibody identification procedures did not distinguish these differences.