Single-dose minocycline in the treatment of gonococcal urethritis. Clinical efficacy in relation to bacterial resistance and its effects on associated Chlamydia trachomatis infections.

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Abstract
Men (72) with gonococcal urethritis were given a single 300-mg dose of minocycline. The failure rate was 13% and the trial was terminated at an early stage. Failure was correlated with increased resistance of Neisseria gonorrhoeae to minocycline. Activity of penicillin, spectinomycin, erythromycin, tetracycline, sulfamethoxazole, cefuroxime, cefotaxime, rosamicin, thiamphenicol and piperacillin against N. gonorrhoeae was examined in vitro. Except for spectinomycin, parallel patterns of resistance to the other antibiotics and minocycline were found. Resistance to spectinomycin was not found, confirming the usefulness of this antibiotic in treatment of gonorrhea. The incidence of PGU [post-gonococcal urethritis] was significantly lower after a single dose of minocycline than in previous studies.