The Induction of Cytolytic T Lymphocytes with Specificity for p-Azophenylarsonate Coupled Syngeneic Cells
Open Access
- 1 October 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 121 (4) , 1432-1436
- https://doi.org/10.4049/jimmunol.121.4.1432
Abstract
Conditions are described for diazonium linkage of the hapten p-azophenylarsonate (Ar) to mouse lymphocytes for the purpose of induction of syngeneic cytolytic T lymphocytes. These cytolytic effector cells do not lyse target cells that are coupled with an unrelated hapten, trinitrophenyl. Cell lysis can be blocked by the addition of anti-Ar antiserum. Only those target cells that share H-2 K or D end antigens with the stimulating cell population are susceptible to lysis. Several methods were used in an attempt to demonstrate the presence of the Ar cross-reactive idiotype on CTL induced in A/J mice.This publication has 9 references indexed in Scilit:
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