Value of Dietary Selenium and Vitamin E for Weanling Swine as Measured by Performance and Tissue Selenium and Glutathione Peroxidase Activities

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Abstract
Three replicates of a 3 ✕ 5 factorial experiment (randomized complete block) were conducted with 360 4-week-old weanling pigs to assess the value of feeding supplemental vitamin E and inorganic Se during a 5-week postweaning period. Pigs were fed 20% protein corn-soybean meal diets containing 0, 10 or 20 IU vitamin E/kg and(or) .1, .3, .5, 1.0 or 2.0 ppm supplemental Se as sodium selenite. At the end of the postweaning trial, 10 pigs from each of the four lower Se treatment groups were fed .1 ppm Se and 10 IU vitamin E/kg to 100 kg body weight for determination of tissue Se carry-over. Pig performance results to 35 days postweaning were similar at all vitamin E and Se levels. Plasma Se initially decreased by 7 days postweaning when .1 ppm Se was provided, but increased when the higher levels were fed. During ensuing weeks, plasma Se increased cubically with increasing levels of dietary Se. Plasma tocopherol decreased within 7 days postweaning in all treatment groups. Supplementation with 10 or 20 IU vitamin E increased plasma tocopherol as the experiment progressed, but no pig group attained the level measured at weaning. Se tissue concentrations increased and plateaued as dietary Se increased, with the liver appearing to be the major storage tissue. Plasma and liver Se concentrations appeared to parallel one another as dietary Se increased. Vitamin E supplementation resulted in lower tissue Se concentrations. Weekly plasma and liver glutathione peroxidase (GSH-Px) activity increased and plateaued with increasing levels of dietary Se. The dietary Se requirement progressively decreased with time postweaning. Breakpoint regression GSH-Px analyses of both plasma and liver estimated the requirement at .35 ppm Se (total concentration) 35 days postweaning. Total or Se-dependent liver GSH-Px increased in a parallel manner to dietary Se levels after 35 days postweaning, while Se-independent GSH-Px was constant. No residual carry-over of tissue Se was evident at 100 kg body weight in any of the postweaning groups. Copyright © 1981. American Society of Animal Science. Copyright 1981 by American Society of Animal Science.

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