A POPULATION STUDY OF HERPESYIRUS INFECTIONS AND HLA ANTIGENS

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Abstract
In a population-based study of herpesvlrus infection and human leukocyte antigen (HLA) phenotype, conducted during the period 1977–1979 In the Framingham Study cohort, HLA-Bw16 was found less often and HLA-Cw2 more often in individuals with histories of herpes labialis than in other individuals. Similarly, both geometric mean antibody titer to herpes simplex type 1 and proportion of Individuals with detectable antibody were higher In those without Bw16 and in tho8e with Cw2. No strong associatIon was found between HLA and history of herpes zoster or titer to herpes simplex type 2, varicella-zoster virus or cytomegalovirus.