Birth order and multiple sclerosis

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Abstract
A correlation has been reported between the development of MS and sibling birth order. We have re-examined the question in 2 groups of MS families. The first group consisted of 175 MS patients from single affected families. The second consisted of 36 families in which 2 or more sibs in the family had MS. Our results show no association between birth order and MS in single-affected sibships. In multiplex sibships, affected individuals appear to be randomly ordered.

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